Bolus dose of 30 mgkg of body weight over 15 minutes, followed by a 45minute pause, and then a 23hour continuous infusion of 5. Methylprednisolone in the management of spinal cord. This randomized clinical trial rct continues the work of the national acute spinal cord injury study nascis group in attempting to treat patients with acute. Methylprednisolone in the management of spinal cord injuries ncbi. The national acute spinal cord injury study nascis 2 and 3 trials are often cited as evidence that highdose methylprednisolone is an efficacious intervention in the management of acute spinal cord injury. Methylprednisolone a haute dose dans le traitement des. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of 41 columna.
Nascis iii mp 3 hrs postraumaticas mp 3 8hrs postraumantismo mantenidos en tx con mp durante 24 horas. Nascis iii randomized 499 patients within six hours of injury. Corticoides dans les traumatismes du systeme nerveux. With certainty, only the most interesting data were reported. In nascis iii it is also likely that all possible comparisons between 0 and 8 hours were made 1 hour and 18 hours, 2 hours and 28 hours, 3 hours and 3 8 hours, and so on. The clinical recommendation of steroid therapy is based generally on the national acute spinal cord injury study nascis ii and iii 276, 286, 289. Nascis iii additionally reported that prolonged steroid use was. Atencion integral al paciente con lesion medular aguda. In the nascis iii protocol, the dose mentioned in nascis 2 for 24 h if patient presents 3. Nascis ii, 1990 was a multicenter, doubleblinded rct that randomized 487 patients with acute traumatic sci to three arms. Pdf highdose methylprednisolone for acute closed spinal cord.
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